Cancer prognostic, diagnostic and treatment methods

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2593325

The invention disclosed herein provides methods comprising detection of EphB2 polypeptide and/or polynucleotide in a biological sample from a subject, wherein the detection of EphB2 is predictive or indicative of cancer prognosis for the subject. The invention also provides methods for selecting cancer treatment, methods comprising detection of EphB2 polypeptide and/or polynucleotide expression in colon adenomas, and methods for treating a colon adenoma disorder. Kits, compositions, and articles of manufacture are also provided.

La présente invention a trait à des procédés comprenant la détection du polypeptide et/ou du polynucléotide EphB2 dans un échantillon biologique provenant d'un sujet, ladite détection de EphB2 étant prédictive ou indicative de pronostic de cancer pour le sujet. L'invention a également trait à des procédés pour la sélection de traitement du cancer, à des procédés comprenant la détection d'expression de polypeptide et/ou du polynucléotide EphB2 dans des adénomes du côlon et à des procédés pour le traitement d'un trouble d'adénome du côlon. L'invention a trait en outre à des trousses, des compositions, et des articles de fabrication.

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