C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2697517
The invention features methods for detecting cancers, especially lung cancer and/or esophageal cancer, using overexpressed gene; CDCA5, EPHA7, STK31 or WDHD1 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing cancers, based on the over-expression or the biological activity of CDCA5, EPHA7, STK31 or WDHD1 in the cancers, especially the interaction between EPHA7 and EGFR. Also, features are a method for treating cancers by administering a double-stranded molecule against CDCA5, EPHA7, STK31 or WDHD1 gene. The invention also features products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
L'invention porte sur des procédés pour détecter des cancers, en particulier le cancer du poumon et/ou le cancer de l'sophage, à l'aide d'un gène surexprimé CDCA5, EPHA7, STK31 ou WDHD1, par comparaison aux organes normaux. L'invention porte également sur des procédés d'identification de composés pour le traitement et la prévention de cancers, sur la base de la surexpression ou de l'activité biologique de CDCA5, EPHA7, STK31 ou WDHD1 dans les cancers, en particulier l'interaction entre EPHA7 et EGFR. L'invention porte également sur un procédé pour le traitement de cancers par administration d'une molécule à double brin dirigée contre un gène CDCA5, EPHA7, STK31 ou WDHD1. L'invention porte également sur des produits, comprenant les molécules à double brin et les vecteurs codant pour celles-ci, ainsi que sur des compositions comprenant les molécules ou vecteurs, utiles dans les procédés selon l'invention.
Daigo Yataro
Nakamura Yusuke
Nakatsuru Shuichi
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
LandOfFree
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