A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/196 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/215 (2006.01) A61K 31/235 (2006.01) A61K 31/24 (2006.01) A61K 31/277 (2006.01) A61K 31/41 (2006.01) A61P 35/00 (2006.01) C07C 235/38 (2006.01) C07D 257/04 (2006.01)
Patent
CA 2400264
A cancer remedy containing a compound represented by the following formula (I) as the active ingredient. In the formula (I), X represents a group represented by either of the following formulae (II) and (III). [R1 and R2 each represents hydrogen, hydroxy, trihalomethyl, C1-12 alkoxy or alkylthio, (substituted) C7- 11 aralkyloxy, or (substituted) C3-10 alkenyloxy; R4 and R5 represents hydrogen, halogeno, C1-4 alkyl, or C1-4 alkoxy; A represents -O-, -S-, -S(=O)- , -S(=O)2-, -CH2-, -OCH2-, -SCH2-, -C(=O)-, or -CH(OR6)-; Y represents hydrogen, halogeno, nitro, nitrile, amino, -COOR7, -NHCOR8, or -NHSO2R9; E represents -C(=O)-, -CR10R11C(=O)-, CH2CH2C(=O)-, or -CH=CHC(=O)-; G represents hydrogen, hydroxy, -SO2NH2, -COOR3, -CN, or tetrazol-5-yl; and Z represents hydrogen, halogeno, nitro, or methyl.]
L'invention concerne un médicament anticancéreux contenant en tant qu'ingrédient actif un composé représenté par la formule (I). Dans cette formule, X est un groupe représenté par l'une des formules (II) et (III). [R?1¿ et R?2¿ représentent chacun hydrogène, hydroxy, trihalométhyle, alcoxy ou alkylthio C¿1-12?, aralkyloxy C¿7-11? (substitué) ou alcényloxy C¿3-10? (substitué) ; R?4¿ et R?5¿ représentent hydrogène, halogéno, alkyle C¿1-4?, ou alcoky C¿1-4? ; A représente -O-, -S-, -S(=O)-, -S(=O)¿2?-, -CH¿2?-, -OCH¿2?-, -SCH¿2?-, -C(=O)- ou CH(OR?6¿)- ; Y représente hydrogène, halogéno, nitro, nitrile, amino, -COOR?7¿, -NHCOR?8¿ ou NHSO¿2?R?9¿ ; E représente C(=O)-, -CR?10¿R?11¿C(=O)-, -CH¿2?CH¿2?C(=O)- ou CH=CHC(=O)- ; G représente hydrogène, hydroxy, -SO¿2?NH¿2?, -COOR?3¿, -CN ou tétrazol-5-yl ; et Z représente hydrogène, halogéno, nitro ou méthyle.]
Kawamura Takashi
Takeyasu Takumi
Tsuchiya Naoki
Tsuruo Takashi
Yamori Takao
Borden Ladner Gervais Llp
Teijin Limited
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