Cancer selective auxotrophs

Details Cancer selective auxotrophs Cancer selective auxotrophs

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 35/74 (2006.01) A61K 39/02 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2572756

Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective antitumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.

L'invention concerne des bactéries auxotrophes pour au moins deux acides aminés présents dans au moins une tumeur, ces bactéries étant efficaces comme agents antitumoraux, comme agents de marquage et comme vaccins contre une infection. On peut conférer des effets antitumoraux améliorés à ces souches par passage à travers un modèle tumoral approprié.

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