Cancer specific glycans and use thereof

Details Cancer specific glycans and use thereof Cancer specific glycans and use thereof

G - Physics

01

N

G01N 33/574 (2006.01) A61K 31/715 (2006.01)

Patent

CA 2658311

The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.

La présente invention a trait à des glycanes, qui sont exprimés par certaines cellules cancéreuses ou d'autres tissus malins. La présente invention a également trait à des procédés pour la détection de glycanes spécifiques du cancer ainsi qu'à des procédés pour la production de réactifs de liaison aux dits glycanes. L'invention a trait en outre à l'utilisation desdits glycanes et leurs réactifs de liaison pour le diagnostic du cancer et d'autres malignités. L'invention a également trait à l'utilisation desdits glycanes et leurs réactifs de liaison pour le traitement du cancer et d'autres malignités. L'invention a trait enfin à des procédés efficaces pour différencier entre des tumeurs malignes et bénignes par l'analyse de structures de glycanes.

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