Cancer specific monoclonal antibodies

Details Cancer specific monoclonal antibodies Cancer specific monoclonal antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01) C12N 5/12 (2006.01) C12N 15/12 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2523452

Novel monoclonal antibodies and binding fragments thereof specific to human breast cancer, lung cancer, colon cancer and other cancers. The monoclonal antibody does not bind to the cell surface of normal human tissues. The corresponding cancer-specific antigen or antigens with an apparent molecular weight of 40-52 130-200 kDa and polynucleotides encoding the antigen and the CDR regions of the antibody are also disclosed, as well as methods for diagnosis, prognosis and treatment of human breast cancer. The antibodies have tumor specificity and are useful for therapy, diagnosis, monitoring, detecting and imaging of cancers. The antibody-recognized cancer-specific surface antigens can serve as targets for detecting, diagnosing, inhibiting or killing cancer cells.

La présente invention concerne de nouveaux anticorps monoclonaux et des fragments de liaison associés spécifiques du cancer du sein, du cancer du poumon, du cancer du côlon et d'autres cancers chez l'homme. L'anticorps monoclonal ne se lie pas à la surface cellulaire de tissus humains normaux. Cette invention a aussi trait à l'antigène ou aux antigènes spécifiques de cancer correspondants ayant un poids moléculaire apparent de 40-52 130-200 kDa, et aux polynucléotides codant l'antigène et les régions CDR de l'antigène, ainsi qu'à des méthodes de diagnostic, de pronostic et de traitement du cancer du sein humain. Lesdits anticorps possèdent une spécificité tumorale et sont utilisés en thérapie, diagnostic, détection et imagerie de cancers. Les antigènes de surface spécifiques de cancer reconnus par les anticorps peuvent servir de cibles dans la détection, le diagnostic, l'inhibition ou l'apoptose de cellules cancéreuses.

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