Cancer specific transcript variants

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2746521

The present inventors here present a novel strategy for identification of RNA transcript variants and demonstrate that these can be correlated to disease states in mammals such as cancer. In particular, the transcript variants show prevalence and specificity to cancer, and thus also show clinical applicability in e.g. cancer diagnostics and prognostics, treatment and therapeutics. The present inventors have identified RNA transcript variants of VNN1 that can be used as biomarkers. The RNA transcript variant may also be used as biomarkers for diagnosing, prognosing, and/or monitoring a cancer.

La présente invention concerne une nouvelle stratégie pour l'identification de variants de transcription d'ARN et démontre que ceux-ci peuvent être corrélés à des états pathologiques chez des mammifères tels que le cancer. En particulier, les variants de transcription présentent une prévalence et une spécificité pour le cancer, et, par conséquent, présentent une applicabilité clinique dans, par exemple, le diagnostic et le pronostic, le traitement et des agents thérapeutiques du cancer. Les présents inventeurs ont identifié des variants de transcription d'ARN de VNN1 qui peuvent être utilisés en tant que biomarqueurs. Le variant de transcription d'ARN peut également être utilisé en tant que biomarqueur pour le diagnostic, le pronostic et/ou la surveillance d'un cancer.

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