Cancer therapeutic agents comprising a ligand for the...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2656227

It is found that a neuromedin U receptor 2 (FM4) molecule is expressed at a high level in a cancer cell such as a pancreatic cancer cell. When a ligand for the molecule is examined on its cancer cell proliferation inhibition effect, it is found that the ligand can inhibit the proliferation of a cancer cell. It is also found that the effect can be produced by a signal via an FM4 molecule. These findings reveal that a ligand for a neuromedin U receptor 2 (FM4) molecule is effective for the treatment of or prevention of the metastasis of cancer having enhanced expression of the neuromedin U receptor 2 (FM4) molecule such as pancreatic cancer.

La présente invention concerne une molécule (FM4) de récepteur 2 de neuromédine U exprimée à un niveau élevé dans une cellule cancéreuse, telle qu'une cellule cancéreuse pancréatique. Lorsqu'on examine un ligand pour la molécule en termes d'effet sur l'inhibition de la prolifération des cellules cancéreuses, on constate que le ligand peut inhiber la prolifération d'une cellule cancéreuse. On constate également que l'effet peut être produit par un signal via une molécule FM4. Ces découvertes révèlent qu'un ligand pour une molécule (FM4) de récepteur 2 de neuromédine U est efficace pour le traitement ou la prévention de la métastase d'un cancer présentant une expression améliorée de la molécule (FM4) du récepteur 2 de la neuromédine U, tel que le cancer du pancréas.

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