C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A01N 61/00 (2006.01) A61K 6/00 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2513251
The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well as recombinant cells containing a SPARC family polypeptide or polynucleotide. The compositions and methods of the invention are useful in in vitro study of cancer therapy resistance, as well as ex vivo and in vivo therapy of cancer.
La présente invention concerne des compositions et des méthodes permettant de rendre sensible une thérapie de cancer. Cette invention a trait à ces compositions contenant un polypeptide ou un polynucléotide de la famille SPARC, ainsi qu'à des cellules recombinantes renfermant un polypeptide ou un polynucléotide de la famille SPARC. Lesdites compositions et méthodes sont utilisées dans une étude in vitro de résistance d'une thérapie de cancer, ainsi que dans une thérapie de cancer ex vivo et in vivo.
Chen Lan Bo
Tai Isabella T.
Dana-Farber Cancer Institute
Torys Llp
LandOfFree
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