Cancer therapy using bcl-xl-specific sina

Details Cancer therapy using bcl-xl-specific sina Cancer therapy using bcl-xl-specific sina

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) C12N 5/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2656107

The invention relates to a double-stranded short interfering nucleic acid (siNA) molecule specific to the Bcl-XL transcript, comprising a sense and an antisense region, wherein the sense region comprises the nucleotide sequence SEQ ID NO: 1 or a sequence having at least 70 % identity, preferably at least 80 % identity, more preferably at least 90 % identity with said sequence, and the antisense region comprises a nucleotide sequence that is complementary to the sense region, and its use for treating cancer.

L'invention concerne une molécule de petit acide nucléique interférant (siNA) double brin spécifique du transcrit Bcl-XL, comprenant une région sens et une région antisens. La région sens comprend la séquence de nucléotides SEQ ID NO : 1 ou une séquence ayant une identité d'au moins 70 %, de préférence d'au moins 80 %, mieux encore d'au moins 90 % avec ladite séquence, et la région antisens comprend une séquence de nucléotides qui est complémentaire de la région sens. L'invention concerne également son utilisation pour traiter le cancer.

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