Cancer therapy using whole glucan particles and antibodies

Details Cancer therapy using whole glucan particles and antibodies Cancer therapy using whole glucan particles and antibodies

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 36/06 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2496596

The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.

L'invention concerne des procédés d'utilisation de particules entières de glucane et d'anticorps d'activation du complément pour la thérapie des tumeurs. Lesdites particules entières de glucane stimulent l'activité tumoricide du système immunitaire naturel par liaison au CR3, récepteur de la protéine C3 du complément. Cette liaison stimule la cytotoxicité du système immunitaire naturel ainsi que la libération de cytokines d'activation.

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