C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/18 (2006.01) A61K 31/135 (2006.01) A61K 31/17 (2006.01) A61K 31/335 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61P 35/00 (2006.01) C07C 217/20 (2006.01) C07C 217/22 (2006.01) C07D 295/112 (2006.01)
Patent
CA 2156162
The in vivo chemotherapeutic treatment of cancer cells in a living animal is improved by first administering to the animal, a compound which inhibits normal cell proliferation while promoting malignant cell proliferation, specifically a potent antagonist selective for intracellular histamine receptors, in an amount sufficient to inhibit the binding of intracellular histamine to the receptors in normal and malignant cells. An enhanced toxic effect on the cancer cells from the chemotherapeutic agent is obtained while any adverse effect of the chemotherapeutic agent on normal cells, particularly bone marrow and gastro-intestinal cells, is inhibited. Certain fluoro derivatives useful in such procedure are novel compounds.
Brandes Lorne J.
Reid Ron
Sim & Mcburney
University Of Manitoba
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