C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C12Q 1/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2200611
Disclosed is a method of reducing or inhibiting the tumorigenicity of a tumor cell in which a vector including a nucleotide sequence encoding a differentiation factor receptor, or a polypeptide portion thereof, is transferred to the tumor cell such that the nucleotide sequence is expressed. Tumorigenicity is monitored by cell growth and colony formation in a semi-soft medium, a reduction in proliferation being indicative of the reduction or inhibition of tumorigenicity of the treated tumor cell.
Procédé de réduction ou d'inhibition de la tumorigénécité d'une cellule tumorale dans laquelle un vecteur comportant une séquence nucléotidique codant pour le récepteur d'un facteur de différenciation ou pour sa partie polypeptidique, est transféré à la cellule tumorale afin de produire la séquence nucléotidique. On peut contrôler la tumorigénécité en observant la croissance des cellules et la formation de colonies dans un milieu semi-mou, une réduction de la prolifération étant l'indication de la réduction ou de l'inhibition de la tumorigénécité de la cellule tumorale traitée.
Lachyankar Mahesh B.
Poluha Dorota K.
Poluha Wojciech
Ross Alonzo H.
Smart & Biggar
Worcester Foundation For Biomedical Research Inc.
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