A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2569132
The present invention relates to a method of treating cancer in a mammal by administration of 4-quinazolinamines and pharmaceutical compositions containing the same. In particular, the method relates to a methods of treating cancers which are mediated by the tyrosine kinases EGFR and/or erbB2 by administration of N-{3-chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2- (methanesulphonyl) ethyl]amino} methyl)-2-furyl]-4-quinazolinamine and salts and solvates thereof.
L'invention concerne un procédé de traitement du cancer chez un mammifère par administration de 4-quinazolinamines, et des compositions pharmaceutiques les renfermant, et en particulier des procédés de traitement du cancer lorsque la médiation du cancer est assurée par tyrosine kinase EGFR et/ou erbB2, par administration de N-{3-chloro-4-[(3-fluorobenzyl) oxy]phényl}-6-[5-({[2-(méthanesulphonyl) éthyl]amino} méthyl)-2-furyl]-4-quinazolinamine, y compris les sels et solvates correspondants.
Berger Mark S.
El-Hariry Iman
Gilmer Tona Morgan
Pandite Arundathy Nirmalini
Rusnak David
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Smithkline Beecham (cork) Limited
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