A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A01K 67/027 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) A61K 49/08 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2333147
Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti- phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.
L'invention concerne la découverte surprenante selon laquelle les aminophospholipides, du type phosphatidylsérine et phosphatidyléthanolamine, sont des marqueurs stables et accessibles à la surface intracavitaire des vaisseaux sanguins de tumeur, et selon laquelle la simple administration d'anticorps vis-à-vis des aminophospholipides suffit à induire la thrombose, la nécrose tumorale et la régression tumorale in vivo. En conséquence, l'invention concerne des procédés reposant sur l'utilisation d'anticorps vis-à-vis des aminophospholipides, et des compositions destinées à être utilisées pour la destruction spécifique des vaisseaux sanguins de tumeur et le traitement des tumeurs solides. Bien que l'invention concerne ainsi plusieurs conjugués et combinaisons d'anticorps, l'utilisation d'anticorps nus ou non conjugués vis-à-vis du type phosphatidylsérine est un aspect particulièrement important de l'invention, grâce à la simplicité et à l'efficacité de l'approche considéréeà
Ran Sophia
Thorpe Philip E.
Board Of Regents The University Of Texas System
R. William Wray & Associates
LandOfFree
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