A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/10 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2331789
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody- therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.
On a découvert que des aminophospholipides, tels que phosphatidylsérine et phosphatidyléthanolamine, sont des marqueurs spécifiques, accessibles et stables de la surface intracavitaire de vaisseaux sanguins tumoraux. L'invention concerne, de ce fait, des produits de recombinaison diagnostiques et thérapeutiques ciblant les aminophospholipides et conçus pour intervenir sur la tumeur. Elle concerne en particulier des conjugués d'agents thérapeutiques et d'anticorps et des produits de recombinaison se fixant aux aminophospholipides, ainsi que des procédés servant à administrer de façon spécifique des agents thérapeutiques, y compris des toxines et des coagulants, aux aminophospholipides d'expression stable de vaisseaux sanguins tumoraux, ce qui provoque une thrombose, une nécrose et une régression de la tumeur.
Brekken Rolf A.
Ran Sophia
Thorpe Philip E.
Board Of Regents The University Of Texas System
R. William Wray & Associates
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