C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/04 (2006.01) A61K 31/282 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2474442
Method for detecting in vitro resistance of cancer cells to a treatment, comprising the step of detecting in the cancer cells supernumerary nucleolar organizer regions (NOR), whereby identification of the presence of supernumarary NOR in the cancer cells is indicative of treatment resistance. And a method for defining the capacity of a candidate agent to modulate NOR genes number of cancer cells, comprising the steps of : contacting the cancer cells with a candidate agent for a time sufficient to permit modulation of NOR genes number; and observing whether NOR genes number increases or decreases in said cancer cells.
Coquelle Arnaud
Dutrillaux Bernard
Gourdier Isabelle
Kroemer Guido
Pau Bernard
Cnrs
Institut Pasteur
Robic
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