Cancer treatment using viruses and camptothecins

Details Cancer treatment using viruses and camptothecins Cancer treatment using viruses and camptothecins

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2562904

Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.

Des sujets mammifères ayant un néoplasme sont traités avec un virus et un composé de camptothécine, par exemple l'irinotécan ou le topotécan. Le virus est choisi dans le groupe constitué du virus de la maladie de Newcastle, d'un virus de la rougeole, d'un virus de la stomatite vésiculeuse, d'un virus de la grippe, d'un virus Sindbis, d'un picornavirus et d'un virus de myxome. Le traitement peut également comprendre d'administration d'un anticorps monoclonal contre un récepteur de facteur de croissance de l'épiderme, par exemple le cetuximab.

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