Cancer treatment with gamma-secretase inhibitors

Details Cancer treatment with gamma-secretase inhibitors Cancer treatment with gamma-secretase inhibitors

A - Human Necessities

61

K

A61K 31/381 (2006.01) A61P 35/00 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01)

Patent

CA 2644136

Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase inhibitor, wherein the regimen results in a reduction in the cancer cell population in the patient In some embodiments of the methods, the therapeutically effective regimen stabilizes, reduces or eliminates the cancer stem cell population.

L'invention concerne des procédés de traitement d'un cancer chez un patient, comprenant l'administration à un patient nécessitant un tel traitement d'un schéma posologique thérapeutiquement efficace qui comprend l'administration d'un inhibiteur de gamma-sécrétase et qui se traduit par une réduction de la population de cellules cancéreuses chez le patient. Dans certains modes de réalisation des procédés, le schéma posologique thérapeutiquement efficace stabilise, réduit ou élimine la population de cellules souches cancéreuses. L'invention concerne également des composés de formule (I), ou leurs sels pharmaceutiquement acceptables, dans lesquels R1, R2 et X ont les significations décrites ici.

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