A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/404 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2454664
A chemotheraputic cancer treatment in which Gö6976 or a compound chemically similar to Gö6976 is administered to a mammal for the treatment of the cancer. The chemical compound is targeted to PKC .alpha. activity. Experiments have shown Gö6976 and similar compounds to be effective for the treatment of breast cancer, leukemia, lung cancer, bone cancer, skin cancer, prostate cancer, liver cancer, brain tumor, cervical cancer, and cancers located in the digestive tract including gastric cancer and colorectal cancers. These treatments may be accomplished utilizing Gö6976 and compounds similar to it alone or in combination with prior art chemotherapy agents or with radiation therapy. In a preferred embodiment Gö6976 is used for the treatment of cancer as a preventative drug by preventing cancel cell formation.
L'invention concerne un traitement chimiothérapeutique du cancer à base de Gö6976, y compris un composé similaire du point de vue chimique. On administre le produit à un mammifère atteint du cancer. Il s'agit de cibler l'action du composé chimique sur l'activité de l'enzyme protéine kinase C alpha (PKC .alpha.). Les expériences réalisées prouvent l'efficacité du composé Gö6976, y compris des composés connexes, pour le traitement de la leucémie et d'autres cancers: sein, poumon, os, peau, prostate, foie, cerveau, utérus, et cancers du tube digestif y compris le cancer gastrique et le cancer colorectal. On peut appliquer le traitement en utilisant le composé Gö6976 et des composés similaires, sous administration isolée ou combinée avec des agents chimiothérapeutiques connus ou bien avec une radiothérapie. En mode de réalisation préféré, on utilise le composé Gö6976 et des composés similaires à titre de médicaments préventifs, dans le cadre de la lutte contre le cancer, en empêchant la formation des cellules cancéreuses.
Lu Zhimin
Wang Keming
Lu Zhimin
Teitelbaum & Maclean
Wang Keming
LandOfFree
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