Cancerous disease modifying antibodies

A - Human Necessities – 61 – K

Patent

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A61K 39/395 (2006.01)

Patent

CA 2530214

The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

La présente invention concerne un procédé permettant de produire des anticorps modifiant la maladie cancéreuse, qui fait appel à un nouveau paradigme de criblage. Le procédé de l'invention, qui sépare les anticorps anticancéreux en utilisant la cytotoxicité pour les cellules cancéreuses comme événement cible, rend possible la production d'anticorps anticancéreux destinés à des fins thérapeutiques et diagnostiques. Les anticorps de l'invention peuvent être utilisés pour diagnostiquer un cancer et en classifier les stades, et pour traiter les tumeurs primaires et les métastases tumorales. Les anticorps anticancéreux peuvent être conjugués à des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.

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