Cancerous disease modifying antibodies

Details Cancerous disease modifying antibodies Cancerous disease modifying antibodies

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2684906

The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

La présente invention concerne un procédé de production d'anticorps modifiant les maladies cancéreuses grâce à un nouveau paradigme de crible. En ségrégant les anticorps anticancéreux en utilisant la cytotoxicité des cellules cancéreuses comme point final, le procédé permet de produire des anticorps anticancéreux à des fins thérapeutiques et diagnostiques. Les anticorps peuvent contribuer à grader et à dépister un cancer, et peuvent être utilisés pour traiter des tumeurs primaires et des métastases tumorales. Ils peuvent être conjugués à des toxines, des enzymes, des composés radioactifs, et des cellules hématogènes.

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