C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2617446
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
La présente invention concerne une méthode permettant de produire des anticorps modifiant une pathologie cancéreuse et faisant intervenir un nouveau paradigme de criblage. En séparant des anticorps anticancéreux avec comme point final une cytotoxicité des cellules cancéreuses, cette rend possible la production d'anticorps anticancéreux à des fins diagnostiques et thérapeutiques. Ces anticorps facilitent la détermination du stade et le diagnostic des cancer et peuvent être utilisés pour le traitement de tumeurs primaires et métastases. Ils peuvent être conjugués à des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.
Cechetto Lisa M.
Hahn Susan E.
Young David S. F.
Arius Research Inc.
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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