Cancerous disease modifying antibodies

Details Cancerous disease modifying antibodies Cancerous disease modifying antibodies

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2668496

The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

La présente invention concerne un procédé de fabrication d'anticorps modifiant une maladie cancéreuse au moyen d'un nouveau procédé de criblage. La ségrégation des anticorps anticancéreux par le biais de la cytotoxicité des cellules cancéreuses en tant que point limite permet au procédé de produire des anticorps anticancéreux à des fins thérapeutiques et diagnostiques. Les anticorps peuvent être utilisés pour aider à diagnostiquer et définir le stade d'un cancer, et peuvent être utilisés pour traiter des tumeurs primaires et des métastases de tumeurs. Les anticorps anticancéreux peuvent être conjugués à des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.

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