Cancerous disease modifying antibodies 180706-02

Details Cancerous disease modifying antibodies 180706-02 Cancerous disease modifying antibodies 180706-02

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2668484

The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

La présente invention concerne un procédé destiné à produire des anticorps modifiant la maladie cancéreuse à l'aide d'un nouveau paradigme d'analyse. En utilisant la cytotoxicité des cellules cancéreuses comme critère d'évaluation pour ségréger les anticorps anticancéreux, le procédé permet de produire des anticorps anticancéreux à visée thérapeutique et diagnostique. Les anticorps peuvent être utilisés dans la stadification et le diagnostic d'un cancer, et peuvent être utilisés pour traiter des tumeurs primaires et des métastases tumorales. Les anticorps anticancéreux peuvent être conjugués avec des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.

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