Cancerous disease modifying antibodies

Details Cancerous disease modifying antibodies Cancerous disease modifying antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2731129

The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

La présente invention concerne un procédé pour produire des anticorps modifiant une maladie cancéreuse utilisant un nouveau paradigme de criblage. Par ségrégation des anticorps anticancéreux en utilisant la cytotoxicité sur des cellules cancéreuses en tant que critère, le procédé rend possible la production danticorps anticancéreux pour des applications thérapeutiques et diagnostiques. Les anticorps peuvent être utilisés pour contribuer à la stadification et au diagnostic dun cancer, et peuvent être utilisés pour traiter des tumeurs primaires et des métastases de tumeur. Les anticorps anticancéreux peuvent être conjugués à des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.

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