C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2644782
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening By segregating anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies such as the monoclonal antibody produced by the hybridoma deposited with the ATCC as accession no PTA-5643. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumours, e g breast or ovarian tumour metastases The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
La présente invention porte sur un procédé de production d'anticorps modifiant une maladie cancéreuse chez un patient, ce procédé utilisant un nouveau paradigme de criblage. En séparant des anticorps anticancéreux sous l'effet de la cytotoxicité des cellules cancéreuses, en vue d'un résultat final, le procédé permet la production d'anticorps anticancéreux tels que l'anticorps monoclonal produit par l'hybridome déposé auprès de l'ATCC sous le No d'accession PTA-5643. Les anticorps peuvent être utilisés à l'aide de la stadification et du diagnostic d'un cancer, et pour traiter des tumeurs primaires, telles que les métastases tumorales du cancer du sein ou des ovaires. Les anticorps anticancéreux peuvent être conjugués aux toxines, aux enzymes, aux composés radioactifs et aux cellules hématogènes.
Findlay Helen P.
Hahn Susan E.
Young David S.f.
Arius Research Inc.
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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