A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/513 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) C07D 239/553 (2006.01)
Patent
CA 2238331
Drugs having an inhibitory activity on thymidine phosphorylases and inhibiting cancerous metastasis, which contain as the active ingredient uracil derivatives represented by general formula (1) or salts thereof, wherein R1 represents chlorine, bromine, iodine, cyano or lower alkyl; and R2 represents an optionally substituted 4- to 8-membered heterocycle having nitrogen, optionally substituted amidinothio, guanidino, lower alkylamidino, amino, etc.
L'invention concerne des médicaments présentant une activité inhibitrice sur les thymidine phosphorylases et inhibant la métastase cancéreuse, lesquels contiennent en tant que principe actif des dérivés d'uracyle représentés par la formule générale (1) ou leurs sels, formule dans laquelle R?1¿ représente chlore, brome, iode, cyano ou alkyle inférieur: et R?2¿ représente un hétérocycle à 4 à 8 éléments facultativement substitués présentant de l'azote, et un amidinothio, un guanidino, un alkylamidino inférieur, un amino, facultativement substitués, etc.
Emura Tomohiro
Miyadera Kazutaka
Wierzba Konstanty
Yamada Yuji
Gowling Lafleur Henderson Llp
Taiho Pharmaceutical Co. Ltd.
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