C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/40 (2006.01) C12N 9/12 (2006.01) C12N 9/16 (2006.01) C12Q 1/18 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2269633
The present invention relates to Candida albicans proteins, such as CaCla4p, Cst20p, CaCdc42p and CaBemlp, associated with virulence and hyphal formation and uses thereof, such as to design screening tests for inhibitors for the treatment of pathogenic fungi infections and/or inflammation conditions. The invention also relates to an in vitro screening test for compounds to inhibit the biological activity of at least one protein selected from the group consisting of CaCla4p, Cst20p, CaCdc42p and CaBemlp, which comprises: a) at least one of said proteins; and b) means to monitor the biological activity of said at least one protein; thereby compounds are tested for their inhibiting potential.
L'invention porte sur des protéines de Candida albicans, telles que les CaCla4p, Cst20p, CaCdc42p et CaBemlp associées à la virulence et à la formation d'hyphes, et sur leurs utilisations notamment pour l'élaboration d'essais de criblage d'inhibiteurs destinés au traitement d'infections et/ou inflammations dues à des champignons pathogènes. L'invention porte également sur un essai de criblage in vitro des composés inhibiteurs de l'activité biologique d'au moins une protéine choisie dans un groupe consistant en CaCla4p, Cst20p, CaCdc42p et CaBemlp, et comprenant: a) au moins une desdites protéines; et b) des moyens de suivre l'activité biologique d'au moins l'une de ces protéines. On peut ainsi vérifier le potentiel inhibiteur des composés.
Leberer Ekkehard
Thomas David Y.
National Research Council Of Canada
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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