Candida kefyr cytosine deaminase

Details Candida kefyr cytosine deaminase Candida kefyr cytosine deaminase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/78 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2506329

A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.

L'invention concerne un nouveau gène et une protéine de cytosine désaminase provenant de Candida kefyr. Cette protéine possède la capacité accrue de transformer le promédicament de 5-fluorocytosine en sa forme toxique par rapport à l'enzyme d'E.coli.

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