Candida kefyr cytosine deaminase

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

IPC codes

C12N 15/55 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/78 (2006.01) C12P 21/02 (2006.01)

Type

Patent

Patent number

CA 2506329

Description

A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.

L'invention concerne un nouveau gène et une protéine de cytosine désaminase provenant de Candida kefyr. Cette protéine possède la capacité accrue de transformer le promédicament de 5-fluorocytosine en sa forme toxique par rapport à l'enzyme d'E.coli.

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