Canine factor viii gene, protein and methods of use

Details Canine factor viii gene, protein and methods of use Canine factor viii gene, protein and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/37 (2006.01) A61K 48/00 (2006.01) C07K 14/755 (2006.01) C07K 16/36 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2264431

The present invention provides isolated nucleic acid molecules encoding canine factor VIII and allelic variants, mutants, fragments or derivatives thereof. The invention also provides canine factor VIII polypeptides encoded by such isolated nucleic acid molecules, antibodies binding to such polypeptides, genetic constructs comprising such nucleic acid molecules, prokaryotic or eukaryotic host cells comprising such genetic constructs, and methods and compositions for use in diagnosing and treating canine disorders characterized by factor VIII deficiency.

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