Canine factor viii gene, protein and methods of use

Details Canine factor viii gene, protein and methods of use Canine factor viii gene, protein and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/37 (2006.01) C07K 14/755 (2006.01) C07K 16/36 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2225189

The present invention provides isolated nucleic acid molecules encoding canine factor VIII and allelic variants, mutants, fragments or derivatives thereof. The invention also provides canine factor VIII polypeptides encoded by such isolated nucleic acid molecules, antibodies binding to such polypeptides, genetic constructs comprising such nucleic acid molecules, prokaryotic or eukaryotic host cells comprising such genetic constructs, and methods and compositions for use in diagnosing and treating canine disorders characterized by factor VIII deficiency.

L'invention fournit des molécules d'acides nucléiques isolées codant le facteur VIII du chien et des variants alléliques, des mutants, des fragments ou des dérivés de ce facteur. L'invention fournit également des polypeptides du facteur VIII du chien codés par ces molécules d'acides nucléiques isolées, des anticorps se liant à de tels polypeptides, des constructions génétiques comprenant de telles molécules d'acides nucléiques, des cellules hôtes procaryotes ou eucaryotes comprenant de telles constructions génétiques, ainsi que des méthodes et des compositions à utiliser dans le diagnostic et le traitement des maladies canines caractérisées par une déficience en facteur VIII.

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