Canine ghrh gene, polypeptides and methods of use

Details Canine ghrh gene, polypeptides and methods of use Canine ghrh gene, polypeptides and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/60 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2524229

The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre- proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-proGHRH or the canine GHRH which can be used to treat disease and growth hormone deficiencies by gene therapy in vertebrates, in particular in dogs.

L'invention concerne un polypeptide canin pré-proGHRH, un peptide canin GHRH mature, et un polynucléotide isolé codant pour le pré-proGHRH canin ou le GHRH canin mature. L'invention concerne également des vecteurs codant pour le pré-proGHRH canin ou le GHRH canin mature et l'exprimant, qui peuvent être utilisés pour traiter une maladie et des déficiences de l'hormone de croissance par thérapie génique chez les vertébrés, notamment les chiens.

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