C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/38 (2006.01) A61K 31/70 (2006.01) A61K 39/245 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C07K 14/03 (2006.01) C07K 14/13 (2006.01) C07K 14/145 (2006.01) C12N 15/869 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2258735
Disclosed and claimed is a recombinant canine herpes virus (CHV). The recombinant CHV includes and expresses at least one heterologous nucleotide sequence encoding an antigen. The antigen can be canine distemper virus HA, canine distemper virus F, rabies virus G, canine parvovirus VP2, parainfluenza virus type 2 HA, parainfluenza virus type 2 F, Borrelia burgdorferi OspA, or Borrelia burgdorferi OspB. The at least one heterologous nucleotide sequence can be in at least one insertion site selected from the group consisting of ORF3 (SEQ ID NO:5), ORF5 (SEQ ID NO:7), the thymidine kinase gene, and the intergenic region corresponding to genes coding for the large subunit and the small subunit. Immunological or vaccine compositions as well as methods for inducing an immunological response are also disclosed and claimed.
Le vaccin vivant recombinant comprend, comme vecteur, un herpèsvirus vaccin comprenant et exprimant au moins une séquence nucléotidique codant pour le polypeptide, cette séquence étant insérée dans un site non essentiel pour la réplication, notamment parmi le groupe consistant en COL3, COL5, gène thymidine kinase, séquence située entre le COL CHV orf19 et le COL CHV orf22, par insertion simple, ou après délétion totale ou partielle.
Audonnet Jean-Christophe
Baudu Philippe
Merial
Smart & Biggar
LandOfFree
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