Canine influenza virus and related compositions and methods...

Details Canine influenza virus and related compositions and methods... Canine influenza virus and related compositions and methods...

A - Human Necessities

61

K

A61K 39/145 (2006.01) C07K 14/11 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2626452

The present invention provides an isolated canine influenza virus of subtype H3N8 comprising an HA having SEQ ID NO: 4 or an amino acid sequence that is greater than 99% identical to SEQ ID NO: 4, with the proviso that the amino acids at positions 94 and 233 are identical to SEQ ID NO: 4; a composition comprising attenuated or inactivated virus; isolated or purified HA, NM, NP, Ml, NSl, PA, PBl, and PB2 proteins and fragments thereof and compositions comprising same or nucleic acids, optionally as part of a vector, encoding same; and a method of inducing an immune response to canine influenza virus in an animal comprising administering to the animal an aforementioned composition.

Cette invention concerne un virus de la grippe canine isolé du sous-type H3N8, lequel virus comprend une protéine HA représentée par SEQ ID NO: 4 ou une séquence d'acides aminés identique à plus de 99% à SEQ ID NO: 4, pour autant que les acides aminés aux positions 94 et 233 soient identiques à SEQ ID NO: 4. L'invention concerne également une composition comprenant un virus atténué ou inactivé; des protéines isolées ou purifiées HA, NM, NP, Ml, NSl, PA, PBl, et PB2 et des fragments de celles-ci, ainsi que des compositions les comprenant ou comprenant des acides nucléiques qui font éventuellement partie d'un vecteur, codant pour celles-ci. L'invention concerne également une méthode permettant d'induire une réponse immunitaire au virus de la grippe canine chez un animal, laquelle méthode consiste à administrer à l'animal l'une des compositions susmentionnées.

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