C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 9/48 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) C12N 15/63 (2006.01) C12N 15/866 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2295957
The present invention relates to canine interleukin 18 and an interleukin 18 production method based on genetic engineering. That is to say, it relates to canine interleukin 18 having at least one of the abilities selected from an ability to act on canine leukocytes and induce antiviral active factors and factors which enhance class II MHC expression on canine tumour cells; an ability to promote canine lymphocyte proliferation; an ability to enhance Fas ligand expression on canine lymphocytes and canine tumour cells; an ability to obstruct and destroy canine tumour cells; an ability to bring about a reduction in size of tumours occurring in the bodies of dogs; and an ability to activate canine leukocytes and suppress canine allergies. Specifically, it relates to canine interleukin 18 having the amino acid sequence shown in Sequence No: 1 or an amino acid sequence comprising part thereof and a method for its production, and a gene coding for this, that is to say a gene coding for the amino acid sequence shown in Sequence No: 1 or an amino acid sequence comprising part thereof; canine interleukin 1.beta. converting enzyme which has the amino acid sequence shown in Sequence No: 2 or an amino acid sequence comprising part thereof and a gene coding for this, that is to say a gene coding for the amino acid sequence shown in Sequence No: 2 or an amino acid sequence comprising part thereof; and a production method where interleukin 18 is produced by insect cells or larvae.
Cette invention se rapporte à l'interleukine 18 canine, à un procédé de production de cette interleukine dans des cellules ou des larves d'insectes, etc. L'interleukine 18 canine possède au moins une aptitude choisie parmi celles d'agir sur les leukocytes canins, pour induire un facteur d'activité antivirale et un facteur de potentialisation de l'expresssion du MHC de classe II sur les cellules tumorales canines, de promouvoir la prolifération des lymphocytes canins, de déteriorer et de détruire les lymphocytes canins et les cellules tumorales canines, de réduire les tumeurs dans les organes vitaux du chien et d'activer les leukocytes canins pour supprimer les allergies chez le chien.
Okano Fumiyoshi
Smart & Biggar
Toray Industries Inc.
LandOfFree
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