Canine rankl and methods for preparing and using the same

Details Canine rankl and methods for preparing and using the same Canine rankl and methods for preparing and using the same

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 19/08 (2006.01) C07K 14/51 (2006.01) C07K 14/705 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2508773

The present invention provides isolated nucleic acid molecules that encode a substantial part of canine RANKL polypeptide, including the extracellular domains of that polypeptide, the polypeptide and fragments thereof. Vectors and host cells encoding and expressing canine RANKL polypeptide are provided, as well as antibodies that bind to RANKL and that inhibit RANKL activity. Also provided are methods of treating an animal to inhibit or treat the loss of bone minerals.

L'invention concerne des molécules d'acides nucléiques isolées qui codent une part sensible du polypeptide RANKL canin, y compris les domaines extracellulaires dudit polypeptide, le polypeptide et des fragments de celui-ci. L'invention concerne également des vecteurs et des cellules hôtes codant et exprimant le polypeptide RANKL canin, ainsi que des anticorps qui se lient au RANKL et qui inhibent son activité. Elle concerne enfin des procédés permettant de traiter un animal en vue d'inhiber ou de traiter la perte de minéraux osseux.

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