Cannabinoid derivatives, methods of making, and use thereof

Details Cannabinoid derivatives, methods of making, and use thereof Cannabinoid derivatives, methods of making, and use thereof

C - Chemistry, Metallurgy

07

D

C07D 311/80 (2006.01) A61K 31/35 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 407/06 (2006.01)

Patent

CA 2526103

1'-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta- 9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type~2 (CB-2). Compounds having activity as either agonists or antagonists of the CB-1 and/or CB-2 receptors can be used for treating CB-1 or CB-2 mediated conditions.

L'invention concerne des dérivés cannabinoïdes 1'-substitués du delta-8-tétrahydrocannabinol, du delta-9-tétrahydrocannabinol et du delta-6a-10a-tétrahydrocannabinol, présentant une affinité pour le récepteur cannabinoïde de type 1 (CB-1) et/ou le récepteur cannabinoïde de type 2 (CB-2). L'invention concerne également des composés possédant une activité agonistes ou antagonistes sur les récepteurs CB-1 et/ou CB-2, pouvant être utilisés pour traiter des états induits par CB-1 ou CB-2.

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