Cannabinoid receptor modulators, their processes of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 209/42 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 207/34 (2006.01) C07D 207/416 (2006.01) C07D 209/00 (2006.01) C07D 231/14 (2006.01) C07D 231/56 (2006.01) C07D 233/90 (2006.01) C07D 257/04 (2006.01) C07D 263/32 (2006.01) C07D 271/06 (2006.01) C07D 285/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 41

Patent

CA 2399791

Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R1-R6 are as defined in the specification, wherein R2 with R5 may form a ring, and/or two R4 groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R6 forming a ring with R3.

L'invention concerne l'utilisation d'un composé pour traiter une maladie respiratoire chez un mammifère dans laquelle le composé est un modulateur de récepteur aux cannabinoïdes. Les composés utiles en tant que modulateurs de récepteurs aux cannabinoïdes pour traiter des maladies respiratoires et non respiratoires associées à l'activation des leucocytes comprennent des composés de la formule (I), dans laquelle A et B représentent l'azote ou le carbone, à condition que seul A ou B représente l'azote; et R¿1?-R¿6? ont la notation figurant dans la description, dans laquelle R¿2? et R¿5? peuvent former un cycle, et/ou deux groupes R¿4? peuvent former un cycle aryle ou hétéroaryle à six éléments, ayant facultativement un substituant R¿6? formant un cycle avec R¿3?.

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