C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/80 (2006.01) A61K 31/35 (2006.01) C07D 311/78 (2006.01) C07D 311/92 (2006.01)
Patent
CA 2340444
Disclosed are novel cannabinoids which are selective for the CB2 receptor. The novel cannabinoids comprise a substituted or unsubstituted tricyclic cannabinoid core and a substituted or unsubstituted C5-C8 carbocyclic ring, five to eight-membered heterocyclic ring or a seven to ten membered bicyclic ring system fused to the monohydroxylated phenyl ring of the cannabinoid core. Also disclosed are methods of suppressing the immune system in a subject by administering to the subject a (e.g. immunosuppressive amount) effective amount of a novel cannabinoid described above.
L'invention concerne de nouveaux cannabinoïdes spécifiques au récepteur CB2. Ces nouveaux cannabinoïdes comprennent un noyau de cannabinoïde tricyclique substitué ou insubstitué et un cycle carbocyclique C5-C8 substitué ou insubstitué, un cycle hétérocyclique à cinq à huit chaînons ou un système bicyclique à sept à dix chaînons fusionné au cycle phénylique monohydroxylé du noyau cannabinoïde. L'invention concerne en outre des procédés pouvant supprimer un système immunitaire chez un sujet par administration à ce dernier d'une quantité effective (p. ex. une quantité immunosuppressive) du cannabinoïde de l'invention.
Khanolkar Atmaram
Lu Dai
Makriyannis Alexandros
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of Connecticut
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