A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2194277
This invention provides methods and combination formulations and kits to reduce the toxicity of camptothecin drugs, such as irinotecan (CPT-11). Disclosed are therapeutics and treatment methods employing such drugs in combination with agents that increase conjugative enzyme activity or glucuronosyltransferase activity, and agents that decrease biliary transport protein activity, such as cyclosporine A, the resultant effects of which are to decrease the significant side effects previously associated with treatment using these drugs.
L'invention concerne des procédés, des formulation combinées et des kits permettant de réduire la toxicité de médicaments à la camptothécine tels que l'irinotécan (CTP-11). Elle porte également sur des procédés thérapeutiques et curatifs dans lesquels ces médicaments sont utilisés conjointement avec des agents augmentant l'activité enzymatique de conjugaison ou l'activité glucuronosyltransférase, et des agents réduisant l'activité protéique de transport biliaire tels que la cyclosporine A, ce qui a pour résultat de réduire les effets secondaires sensibles associés auparavant au traitement par ces médicaments.
Gupta Elora
Ratain Mark J.
Arch Development Corp.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
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