Capecitabine rapidly disintegrating tablets

Details Capecitabine rapidly disintegrating tablets Capecitabine rapidly disintegrating tablets

A - Human Necessities

61

K

A61K 9/36 (2006.01) A61K 9/00 (2006.01) A61K 31/7068 (2006.01)

Patent

CA 2745279

There is provided a film coated pharmaceutical composition comprising 5'-deoxy- 5-fluoro-N-[(pentyloxy)-carbonyl]-cytidine (capecitabine) and at least one disintegrant selected from the group comprising of crospovidone (particle size < 15-400 µ), croscarmellose sodium, sodium starch glycolate, low- substituted hydroxypropylcellulose, Ludiflash ® or any combination of these, together with other pharmaceutically acceptable excipients to form a rapidly disintegrating tablet.

L'invention porte sur une composition pharmaceutique revêtue d'un film comprenant de la 5'-désoxy-5-fluoro-N-[(pentyloxy)-carbonyl]-cytidine (capécitabine) et au moins un agent de désintégration choisi dans le groupe constitué par la crospovidone (dimension de particule < 15-400 µ), le sodium de croscarmellose, le glycolate d'amidon sodique, l'hydroxypropylcellulose faiblement substituée, le Ludiflash® ou toute combinaison de ceux-ci, conjointement avec d'autres excipients pharmaceutiquement acceptables pour former un comprimé se désintégrant rapidement.

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