A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/46
A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61K 51/12 (2006.01)
Patent
CA 2005820
CAPILLARY DEPLETION METHOD FOR QUANTIFYING TRANSCYTOSIS THROUGH THE BLOOD-BRAIN BARRIER ABSTRACT A method for quantifying transcytosis through the blood-brain barrier by infusing a perfusate into the brain of a living mammal. The perfusate includes a radio-labelled test compound and a radio-labelled marker compound. The perfused brain is removed from the animal and homogenized. The homogenized brain is separated into a microvasculature fraction and a supernatant fraction. The net volume of distribution of the test compound in the supernatant is calculated and corrected to provide an accurate measure of transcytosis through the blood brain barrier.
Pardridge William M.
Swabey Ogilvy Renault
The Regents Of The University Of California
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