Capillary electrophoretic method to detect target-binding...

Details Capillary electrophoretic method to detect target-binding... Capillary electrophoretic method to detect target-binding...

G - Physics

01

N

G01N 27/447 (2006.01)

Patent

CA 2316290

The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one to rank various ligands based on their relative affinity, i.e., the relative stability of the target/ligand complex during capillary electrophoresis under selected conditions. The method also enables selective detection of strong-to-moderate binding hit compounds, even in the presence of high concentrations of weaker, competitive hit compounds.

L'invention concerne des procédés électrophorétiques capillaires permettant de détecter des ligands ou des composés incidents qui peuvent se lier à une cible sélectionnée à ou au-dessus d'une force de liaison sélectionnée. Le procédé permet à l'un d'entre eux d'ordonner divers ligands selon leur affinité, par exemple la stabilité relative du complexe cible/ligand pendant l'électrophorèse capillaire dans des conditions sélectionnées. Le procédé permet aussi une détection sélective de composés incidents de liaison forte à modérée, même en présence de concentrations élevées de composés incidents compétitifs plus faibles.

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