Capl-specific oligonucleotides and methods of inhibiting...

Details Capl-specific oligonucleotides and methods of inhibiting... Capl-specific oligonucleotides and methods of inhibiting...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12N 9/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2213233

Disclosed are synthetic oligonucleotides, including ribozymes, having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

L'invention concerne des oligonucléotides dont des ribozymes comprenant une séquence nucléotidique complémentaire de l'acide nucléique de CAPL. Elle porte aussi sur des procédés d'inhibition de l'expression du gène CAPL et du cancer métastatique à l'aide d'oligonucléotides spécifiques de CAPL.

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