Capsid forming and cystein modified chimaeric ms2-coat protein

Details Capsid forming and cystein modified chimaeric ms2-coat protein Capsid forming and cystein modified chimaeric ms2-coat protein

C - Chemistry, Metallurgy

12

N

C12N 15/40 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/08 (2006.01) C07K 14/11 (2006.01) C07K 19/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2111683

2111683 9300434 PCTABS00019 A chimaeric protein is provided, capable of forming part of a capsid assembly and comprising the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain the capability of forming a capsid assembly, which amino acid sequence has been modified by removal of the cysteine residues present externally of the N-terminal protuberant .beta.-hairpin of the coat protein and insertion of a cysteine residue within the region corresponding to the N-terminal protuberant .beta.-hairpin.

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