A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2384827
The present invention describes a recombinant adenoviral vector in which a single-chain antibody has been introduced into the minor capsid proteins, pIIIa or pIX, so that the adenoviral vector can be targeted to a particular cell type. Additionally disclosed is a method of using the recombinant adenoviral vector in targeted gene therapy.
La présente invention concerne un vecteur adénoviral recombinant dans lequel on a introduit un anticorps à chaîne simple dans les protéines de capside mineures pIIIa or pIX de manière à cibler vecteur adénoviral en fonction d'un type de cellule déterminé. L'invention concerne en outre un procédé d'utilisation du vecteur adénoviral recombinant dans la thérapie à ciblage de gènes.
Borden Ladner Gervais Llp
The Uab Research Foundation
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