Capsid proteins and uses therefore

Details Capsid proteins and uses therefore Capsid proteins and uses therefore

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 39/29 (2006.01) A61P 1/16 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/02 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C07K 14/025 (2006.01) C07K 14/35 (2006.01)

Patent

CA 2691033

Provided is a composition comprising a fusion protein and a desired antigen, wherein the fusion protein comprises a chaperone protein like heat shock protein 65 and a capsid protein like HBV core antigen, which can produce immunogenic macro-molecular structures as antigen carrier. Also provided are preparation methods of the composition, which comprise purifying recombinant capsid proteins in the presence of chaotropic agents like urea or guanidine hydrochloride, and reassembling of the denatured recombinant capsid proteins. The composition can be used for therapeutic or prophylactic vaccination.

L'invention concerne une composition contenant une protéine de fusion et un antigène désiré. La protéine de fusion comprend une protéine chaperon telle que la protéine de choc thermique 65 et une protéine de capside telle que l'antigène du noyau du VHB, pouvant produire des structures macromoléculaires de transport de l'antigène. L'invention concerne également des méthodes de préparation de ladite composition, consistant à purifier des protéines de capside de recombinaison en présence d'agents chaotropiques tels que l'urée ou l'hydrochlorure de guanidine, et à réassembler les protéines de capside de recombinaison dénaturées. Cette composition peut être utilisée à des fins de vaccination thérapeutique ou prophylactique.

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