Capsular polysaccharide metal complex vaccines

Details Capsular polysaccharide metal complex vaccines Capsular polysaccharide metal complex vaccines

A - Human Necessities

61

K

167/119, 167/129

A61K 39/02 (2006.01) A61K 39/095 (2006.01)

Patent

CA 1259917

ABSTRACT Improved Complexes, Processes for obtaining them and Formulations containing such complexes Complexes comprising a metal constituent and a bacterial capsular polysaccharide constituent, wherein the polysaccharide contains sialic acid, are useful in the prophylaxis and treatment of bacterial diseases. The polysaccharide is preferably colominic acid or meningococcal group B polysaccharide. Preferred metals are aluminium and ruthenium. The complexes preferably also contain a third constituent of bacterial outer-membrane protein. Some of the complexes, especially when formulated as vaccines, are particularly applicable in the prophylaxis and treatment of cerebrospinal meningitis.

487528

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