Capsule membrane formation technique

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 11/02 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) B01J 13/08 (2006.01) B01J 13/20 (2006.01) C12N 5/00 (2006.01) C12N 5/16 (2006.01)

Patent

CA 1238273

Abstract of the Disclosure Disclosed is an improved process for encapsulating core materials, particularly viable cells, within a membrane of controlled porosity. A polyanionic polymer, e.g., sodium alginate, is formed into shape-retaining gel masses. The gelled masses are then expanded by hydration, and a membrane is formed by reaction at the surface of the expanded masses with a polyanionic polymer having a molecular weight greater than 3000. The expansion step promotes the formation of continuous, uniform capsule membranes of more consistent permeability resulting in a more reproducible cell encap- sulation process.

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